a tool for identifying drug-targetable redox-active disulphides

Protein Tat

Intermolecular

Cysteine 261 of Cyclin-T1 and cysteine 27 L

A redox-regulated disulphide may form between cysteine 261 of Cyclin-T1 and cysteine 27 of Protein Tat.

Details

Redox score ?

74

PDB code

Structure name

crystal structure of hiv-1 tat complexed with human p-tefb and aff4

Structure deposition date

2014-02-10

Thiol separation (Å)

4

Half-sphere exposure sum ?

51

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Cyclin-T1

Peptide B name

Protein Tat

Peptide A accession

Peptide B accession

Peptide A residue number

261

Peptide B residue number

27

Ligandability

Cysteine 261 of Cyclin-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Protein Tat

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: